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ENW EndNote. We previously noted that Ig expression and activity in cancer cell lines could be blocked by specific antisense DNAs and antibodies, causing the cancer cells to undergo apoptosis These data suggest that non-B-cell-derived Ig is involved in the growth and survival of cells. In summary, many nonhematopoietic tumor cells express Ig. The cancer-derived Ig gene repertoire displays several distinct characteristics, suggesting that there is an idiosyncratic mechanism for cancer-derived Ig gene expression. The gene expression patterns of Ig in different cancer cells may prove useful in understanding the structure and function of nonhematopoietic-derived Ig.
In addition, these findings may have important implications for the diagnosis, targeted therapy, as well as monitoring of residual disease of cancers. We thank Dr. Dalong Ma, Dr.
IMMUNOGLOBULIN GENES: CONCEPT OF DNA REARRANGEMENT
Lieping Chen from the Dept. Jiang Gu, and Dr. Michael A. McNutt from the Dept.
Yu Zhang and Dr. Yanhui Yin from the Dept. We also thank I. You'll be in good company. Journal of Lipid Research. Previous Section Next Section. View this table: In this window In a new window. TABLE 3 Seven sets of predominant V H DJ H recombinants found in different cancer types The clone name appears in four letters as follows: the first represents the tissue of origin B for breast cancer, L for lung cancer, C for colon cancer, O for oral cancer, and H for HT cell line ; the second represents immunoglobulin isotype G for IgG, and M for IgM ; the third represents the patient number; and the last number in brackets represents the number of clones in this set of V H DJ H rearrangements.
Previous Section. Jerne, N. Glick, B. Google Scholar. Mitchell, G. Tonegawa, S. Hozumi, N. Neri, A. Cleary, M. Fraternali-Orcioni, G.
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CrossRef Medline Google Scholar. Bartram, C. Zuniga, M. Olubuyide, I. Medline Google Scholar. Manjula, S. Wien , Taylor, D. Tenenbaum, N. Interne Paris , 89 Hori, H. Gregersen, H. Qiu, X. Wang, D. Beijing Med. Kimoto, Y. Li, M. Cell Biol. Babbage, G. Zhu, X. Lefranc, M. Nzula, S. Messmer, B. Hansen, M. Previous Section Next Section. Active Ig genes of plasma cells exhibit pronounced colocalizations in transcription factories, often near the nuclear periphery Transcription of genes by RNA polymerase II Pol II occurs at transcription factories, which are clusters of approximately eight Pol II molecules that colocalize as nuclear foci in fixed or living cells Cook ; Edelman and Fraser ; Cisse et al.
Figure 1. Figure 2.
Editing of mouse and human immunoglobulin genes by CRISPR-Cas9 system
Figure 3. Figure 4.
Additional materials and methods are provided in the Supplemental Material. Previous Section. Proc Natl Acad Sci : — Blobel G Blobel G.
Gene gating: a hypothesis. Proc Natl Acad Sci 82 : — Three-dimensional organization of chromatids by nuclear envelope-associated structures. Chromatin topology and the regulation of antigen receptor assembly. Annu Rev Immunol 30 : — Science : — The organization of replication and transcription.
Capturing chromosome conformation. Transcription factories: genetic programming in three dimensions.
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- Immunoglobulin Genes.
Curr Opin Genet Dev 22 : — CrossRef Medline Google Scholar. Interphase nuclei of many cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol : — Genes Dev 27 : — Immunity 5 : — Nature : — Immunoglobulin assembly and secretion. In Molecular biology of B cells ed.
T Honjo T, et al. Elsevier, London. Google Scholar. Chromatin dynamics. Ann Rev Biophys 39 : — CrossRef Google Scholar. A dynamical model reveals gene co-localizations in nucleus. Plos Comp Biol 7 : e Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. The promoter of the immunoglobulin J chain gene receives its authentic enhancer activity through the abutting Mef2 and PU.
J Mol Biol : — Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol 13 : — Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing. Nat Immunol 10 : —
Related Immunoglobulin Genes
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